شماره ركورد كنفرانس :
3693
عنوان مقاله :
Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Gastric Cancer Cells
پديدآورندگان :
Alemi Ashraf alemi.ashraf@gmail.com Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences , Jahanbani Raheleh Institute of Biochemistry and Biophysics, University of Tehran , Entezari Nasab Zakieh Department of Pediatrics, Semnan University of Medical Sciences , Farrokhifar Ali Faculty of Medicine, Aja University of Medical Sciences , Farrokhifar Seyed Hamid Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University
كليدواژه :
Chemotherapy , Niosome , Curcumin , Nanoparticle
عنوان كنفرانس :
اولين كنگره بين المللي زيست پزشكي ICB2017
چكيده فارسي :
Curcumin, a natural polyphenolic compound found in Curcuma longa, has been utilized in multiple medicinal areas from antibiotic to antitumor treatment. However, the chemical structure of curcumin results in poor stability, low solubility, and rapid degradation in vivo, hampering its clinical utilization. To overcome these issues, we have developed a novel Niosome system composed of nonionic surfactants Tween 60and cholesterol. Curcumin was encapsulated in the Niosomes with a high entrapment efficiency of 98.4 ± 0.4 %. Niosomal Curcumin exhibited enhanced cytotoxic activity against Gastric cancer AGS cells compared with freely dispersed curcumin. These findings demonstrate that the Niosomal Curcumin system is a promising strategy for the delivery of Curcumin and Gastric cancer therapy.
