RAFT polymerization technique for the synthesis of polymers containing the dye or drug

Nowadays, one of the concerns of human society is the cancer topic, according to numerous cancer-causing factors in the developed world.In order to overcome these problems today, drugs targeting strategy is used. Targeted drug delivery is often divided into two categories, passive and active.In active targeting, therapeutic agent along with a carrier, attached to a specific cell or tissue. Active targeting benefits include of ability to maintain drug concentration in relatively constant for a specified period of time, the possibility of delivering medicine to a particular organ or tissue, take delivery in nanometer dimensionsand etc[1,2]. We report the synthesis of a water-soluble polymer containing functional groups using RAFT polymerization technique. These polymers have a narrow molecular weight (PDI low) and is connected to an active molecules, such as dyes, drugs or antibodies. The RAFT process involves conventional free radical polymerization of a substituted monomer in the presence of a suitable chain transfer agent (RAFT agent). Sothe first step is the formation oftheNacryloxysuccinimide( NAS)monomer,next the synthesis of pentafluorophenyl[4- (phenylthiocarbonylthio)-4-cyanovalerate] (CTA-PFP) as RAFT agent and eventuallythe synthesis of polymerthrough RAFT polymerization in Schlenk flask. These starting materials and polymerwere characterized by FT-IR and 1HNMR