(Z)-2-(1-(4-Methoxyphenyl)-2-phenylethylidene)hydrazinecarboximidamide Derivatives as Antiseizure Agents

Epilepsy is a common neurological disorder characterized by recurrent seizures that affect about 1% of the world‘s population[1].Despite all the new antiepileptic drugs (AEDs) introducedin the last two decadesabout 30% of patients have uncontrolled seizures. Inaddition all AEDs have side effects. Consequently, there is a significant need to develop new more efficacious AEDs that will be more potent and with less side effects[2]. Hydrazones and their derivatives are known to exhibit a wide range of interesting biological activities like antioxidant, anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anticancer, antiprotozoal, antioxidant, antiparasitic, antiplatelet, cardioprotective, anthelmintic, antidiabetic, antitubercular, trypanocidal, anti-HIV, and so forth. The present review summarizes the efficiency of hydrazones as potent antiseizure agents [3]. A series of novel (Z)-2-(1-(4-Methoxyphenyl)-2-henylethylidene) hydrazinecarboximidamides was prepared via two step reaction. A structure–activity relationship was established focusing on the influence of the substitution pattern in para position of the aryl moiety (Scheme 1). Some of the compounds proved to be as potential antiseizure agents.