4Sufophthalic acid as an efficient catalyst for the multicomponent one-pot synthesis of substituted pyrazolones in aqueous media

The research in multi-component reactions (MCRs) is a hot topic of organic chemistry because of their advantageous in the preparation of different heterocyclic molecules and in drug discoveryprocedures[1]. Although MCRs are efficient, environmentallyfriendly, fast, atom economic and time saving style. They supplyan effective tool for the preparation of various compounds withpharmaceutical and biological properties[2]. One type of thesereactions is the synthesis of pyrazolones which display biologicaland pharmacological properties.In order to develop a new method for the synthesis of Pyrazolones, we report here 4-sulfophthalic acid assisted synthesis of Pyrazolones, from the condensation of phenyl hydrazines, ethyl acetoacetate ,β-naphthol and benzaldehydes in water as solvent at in reflux condition.