A One-Pot multicomponent reaction for facile synthesis of novel 2-((1H-Benzo[d]imidazol-2-ylamino) (Aryl) methylthio) Acetic acid by La(NO3)3.6H2O as an efficient catalyst

Heterocycles containing 2-aminobenzimidazole moiety exhibit a large variety of biological activities including inhibitors of HIV-1 reverse transcriptase, antitumor, anticancer, antihepatitis C virus (HCV), antiviral, antibacterial and antifungal activities [1]. Multicomponent reactions (MCRs) are known as one pot reaction in which three or more easily accessible compounds are combined in a single reaction vessel. MCRs also increase the efficiency by combining several operational steps without isolation of intermediates or changing the reaction conditions. Speed and short reaction time, diversity, efficiency and environmental amiability, easy work up, good to excellent yields are some of the major advantages of these reactions [2-3]. The conventional methods for the synthesis of Schiff‘s bases require long reaction times and use of organic solvents [4]. We report an eco-friendly One-Pot multicomponent reaction permitting the ‗‗green synthesis‘‘ of 2-(1H-Benzo- [d]imidazole-2-ylamino)(aryl)methylthio acetic acid analogs by stirring 2- aminobenzimidazole and thioglycolic acid with various aromatic aldehydes in solid state at 80˚C and in the presence of La(NO3)3.6H2O as an efficient homogeneous catalyst. This method is experimentally simple, clean, high yielding, green, and with reduced reaction times. The reaction followed by adding water and filtering the solid product at room temperature and drying them in vacuum condition.