چكيده فارسي :
The 3,4-dihydrocoumarin system is widely distributed in nature [1], and some derivatives
have shown a wide range of biological activitiessuch as aldose reductase inhibition,
antiherpetic, protein kinases, and a moderate estrogenic activity [2]. A variety of3,4-
dihydrocoumarines were synthesized multi component reactions [3].
As a part of our current studies on the isocyanide-based multi component reactions, in this
work,fluorinatedcoumarineshas been synthesized viafour-component reaction. A wide variety
of pharmacologically significantand structurally interesting compounds were
preparedviausing commerciallyavailablesubstituted 2-hydroxybenzaldehydes 1, Meldrum‘s
acid 2, isocyanides 3,andfluoroalcohol4 inCH2Cl2 at room temperature without using any
catalysts and activation in excellent overall yields (Scheme 1).Substituents could be
independently varied at three different positions.
