Synthesis of new antibacterial nanocomposite based-Cubane and its application in combination cancer therapy

Explosives and Drugs are two completely different categories so that one destroys and the other cures. But now it has been proved that these two different manners exist in an eightcarbon box-shape compound called cubane simultaneously. The first usage of the cubane in medicinal chemistry returns to a patent in 1971.The mentioned compounds in this report were the potent antiviral agents [1]. Resistance of cancer cells to chemotherapy drugs is the most challenging part of cancer therapy that could be omitted when multiple drugs are delivered simultaneously; though, different drugs target different components of the cancer cell. The combined therapy from more than one anticancer drug can produce the optimal therapy effect [2].On the other hand, the body s immune system under chemotherapy become weak and susceptible to infectious diseases, so the during of chemotherapy for these patients, antibiotics are prescribed. Regardless of great amount of antibiotics and chemotherapeutics accessible for medical use, meanwhile the growing number of multi-drug resistant microbial pathogens produced in the last decades revealed an extensive medical requirement for novel antimicrobial agents [3]. In this study based-silica polymeric nanocarrier with anticipating the anti-bacterial properties was designed and developed as dual anticancer drug delivery system. The chemical structure, stimuli responsive co-delivery of anticancer drugs, anti-bacterial and anti-tumoral property of the developed system was fully characterized.