Synthesis of N-phenylacetamide and arylcarboxyamide by using aryl diazonium silica sulfates under mild conditions

Aromatic diazonium salts have been prepared and studied for years. These salts are important building blocks in classical and modern organic synthesis, and interest in these versatile and reactive species remains high [1]. Although diazonium salts have wide applications in the synthesis of various compounds, these salts have a serious drawback in their intrinsic instability and explosive potential. Therefore, these compounds are usually synthesized at around 10 °C, and to avoid their decomposition, they are handled below 0 °C [2].Thus, aryldiazonium salts with higher stability and versatility that can be easily made and stored under solid state conditions with explosion-proof properties are desired and necessary. In continuation of our studies on the application of stable diazonium salts [3,4[,herein, we wish to report an efficient, fast and straightforward procedure for the synthesis of Nphenylacetamide and arylcarboxyamide using aryl diazonium silica sulfates in the presence of acetonitrile orisocyanides. Using the present method, different kinds of aryl diazonium silica sulfates, containing electron withdrawing groups as well as electron donating groups, were rapidly converted to the corresponding of N-phenylacetamide and arylcarboxyamide in good yield. Simple and clean work-up, and good yields were the advantages of this method.