چكيده فارسي :
As one of the known MCRs, Hantzsch reaction has attracted much attention on the
synthesis of 1,4-dihydropyridines (1,4-DHPs) due to their significant biological and
pharmacological properties such as antitubercular ,anticonvulsant, antitumour ,analgesic, antiinflammatory
and stress protective activities [1].
Hybrids of organic-inorganic materials are of great interest as heterogeneous catalysts in
organic synthesis, since the functionality and flexibility of organic moiety as well as thermal
and structural stability of inorganic solids are collected in these systems [2].Their large
surface area per unit volume, a consequence of their small diameter, makes them interesting
in the area of heterogeneous catalysis; Heterogeneous catalysis in the nano-scale takes
advantage of a high exposure of the active species leading to a higher efficiency of the
catalyst [3].
Considering the importance of MCRs and the diverse applications of 1,4-DHPs and the
limitation with the previous synthetic routes and our earlier interest in green procedures of
MCRs and recyclable organic-inorganic nanocatalysts [4], we wish to report an efficient and
convenient methodology for the Hantzsch reaction by One-Pot cyclocondensation of
aldehydes, ammonium acetate and ethylacetoacetate under mild and green conditions
(Scheme 1).
