Synthesis of Pyrrolobenzothiazole Derivatives from Benzothiazole and Acetylenic Esters

Molecules that contain benzothiazole moieties are attractive targets fororganic synthesis because they often exhibit diverse and important biological properties [1]. Therefore, thesyntheses of benzothiazole derivatives have received an increasing attention to synthetic organic chemists and medicinal chemistry [2]. Pyrrolo[2,3]benzothiazole cyclization reactions of 2-methylbenzothiazole with dialkylacethylcarboxylates/alkylpropiolates and succinimide at room temperature under metal- and radiation- free conditions are described. Various aspects of these transformations will be presented and discussed.