Synthesis of some Dihydro-Dipyrido-Triazine Systems from Pentafluoropyridine

Heterocyclic compounds have increasing important in the pharmaceutical industry and the most of important life-science products are contain heterocyclic structures [1,2].Halogen substituents atdifferent positions of heteroaromatic systemsring indicate different reactivity tonucleophiles, for example in pentafluoropyridine order reactivity toward nucleophilic attack follow the sequence 4-F 2-F 3-F [3-4]. In this work we report the synthesis of some dihydro-dipyrido-triazine Systems via reaction of 1,6- diamino- 2- oxo- aryl- 1,2- dihydropyridine- 3,5- dicarbonitrile (1)with pentafluoropyridine(2) in the presence of potassium carbonate in CH3CN at reflux temperature (Figure 1). All fluorinated products were confirmed with NMR Spectra.