One-Pot Three Compounds Synthesis of Spirooxindole Derivatives using CuFe2O4 Nanocatalyst in Water

Interest in spiro[3,3′-oxindoles], i.e. having an oxindole nucleus but with a spirocyclic ring fused at C-3 [1], The unique structural features of spiroheterocycles and the presence of spiro linkage as a basic skeleton of antimicrobial, antitumor, hypotensive, antileishmanial, and local anesthetic agents [2] have increased their importance to a great extent. The multi component reaction or MCR strategy has been successfully adopted by many researchers for the synthesis of spirooxindoles [3]. In this study we report a simple and efficient method for the synthesis of spirooxindoles by the three component One-Pot condensation of 5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolone - 1,2(4H)-dione, ethyl 2-cyanoacetate, and cyclic 1,3-diketones using CuFe2O4nanocatalyst as a green and reusable catalyst (Figure 1).