Synthesis, Antibacterial Activity of New Dihydropyrrol-2-one Derivatives Bearing Sulfonamide Groups

The design and development of novel pharmaceuticalcompounds with a broad spectrum of activities is still a major challenge to medicinal chemistry researchers by reason the rapid appearance microbial resistance in humans and some animals. Dihydropyrrol-2-one derivatives are well known as the most important nitrogen-containing heterocyclic compounds due to their present in many natural products, synthetic pharmaceuticals, and molecular materials [1, 2].Sulfonamides have attracted much attention of chemical chemists because of pharmacological and biological activities [3, 4]. Due to the pharmacological and biological importance of sulfonamides, nitrogen-containing heterocyclic compounds in medicinal chemistry, the synthesis of compounds bearing sulfonamide moieties with the aim of outstanding biological properties has become interesting field in research. A series of novel dihydropyrrol-2-one derivatives bearing sulfonamide groups in high yields via three-component reaction under catalyst-free and solvent-free conditions. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, and green procedure, catalyst-free and solvent-free conditions. Antibacterial results showed that most of the compounds displayed good antibacterial activity against P.aeruginosa bacteria.