Synthesis, characterization of new azomethine compounds based on aminophenol moiety and evaluation of their antibacterial properties

Schiff base which contain an azomethine group attract much interest in synthetic chemistry. Schiff base imports in elucidating the mechanism of transformation reactions in biological systems due to presence of imine (-N=CH-) group[1]. AzoSchiff bases are used as substrate in the preparation of a number of industrial and biologically active compounds via closure, cycloaddition and replacement reactions. Moreover,azomethineare also known to have biological activities such as antibacterial [2], antifungal and antitumoractivities [3]. In the present investigation, a series of newly azo Schiff bases containing aminophenol derivatives synthesized for evaluating of their possible antibacterial activity.New compounds were synthesized from 2-hydroxy-5(pyridine-4-yl-diazenyl)benzaldehyde and n-aminophenol in absolute ethanol.The structures of thenewly synthesized compounds have been confirmed on the basis (IR, 1HNMR, and 13CNMR spectroscopy).Antibacterial activityof synthesized compounds againstBacillus cereus, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniawas studied by disc diffusion method.The results indicated that some of the prepared compounds had antibacterial activities against Gram-positive bacteria (S. aureus and B. cereuss), but they were slightly active against Gram-negative bacteria (E. coli and K. pneumonia).