چكيده فارسي :
Organic sulfides are important compounds which widely exist in many biologically and
pharmaceutically active molecules. Especially unsymmetrical sulfides moieties have been
used in the treatment diseases such as Parkinson,s, Alzheimer,s, immune and inflammatory,
diabetes, HIV [1,2].
Carbon-sulfur bond formation by cross-coupling reaction in the presence of transition
metals has been widely investigated. Metal-organic frameworks (MOFs) have recently
aroused much attention as a new class of nanoporous material that can used as an effective,
heterogeneous, and recyclables in coupling reactions [3]
As a part of our current studies on the synthesis of Organosulfurs compounts, we report the
results of our studies involving the reaction between iodobenzene and thios in the presence
MOF-199 as a catalyst, KOH in wet PEG(400) at 120 oC under an N2 atmosphere conditions.
High yields were obtained and MOF-199 catalyst was easily isolated from the reaction
mixture by simple filtration and reused with loss in activity
Herein, a new application of MOF-199 as a heterogeneous catalyst in these type crosscoupling
reactions is described. MOF-199 is as a porous, recyclable and chemoselective
catalyst which is more efficient more economic, more comprehensive, and more
environmentally friendly than previous catalyst..
