Use of CaCO3@Fe3O4 nanoparticles as an efficient and eco-friendly nanocatalyst for facile synthesis of perimidine derivatives

Perimidines are tricyclic heterocycles containing a dihydropyrimidine ringortho and perifused to the naphthalene structure. These heterocyclic systems,which have been shown to be interesting candidates for biological studies, arewidely applied in industry, agriculture, and medicine [1]. Magnetic porous hollow nano-sphere is a new class of structured nanomaterials for drug delivery, magnetic resonance imaging, hyperthermia cancer treatment, and bioseparation[2].Magnetically Fe3O4/CaCO3recoverable nanoparticles represent an economical, practical and environmentally benign means for catalyst recovery [3]. The nanocatalyst was characterized by IR, EDX, scanning electron microscopy (SEM) and TEM. The some novel compounds were identified by spectroscopic and spectrometric analyses.This environmentally benign and clean synthetic procedure has several advantages, including the availability, safety, and reusability of the catalyst, high yields, short reaction times, and easy and rapid isolation of the product. Encouraged by this result and the development and generality of a simple method for synthesizing of heterocyclic compound, One-Pot reaction of 1,8-diaminonaphthalene 1 with a variety of aromatic aldehydes 2 by using of Fe3O4@CaCO3 nanoparticles as highly efficient catalyst in ethanol at room temperature was performed (Figure1).