C-N Bond Cleavage: A Novel Access to Sulfonamides

Due to their efficient anticancer, antitumor, anticonvulsant, antibacterial, antiinflammatory as well as HIV protease inhibitory, sulfonamides have found paramount importance as structural motifs in pharmaceuticals and biologically active compounds [1]. Being potent inhibitors of carbonic anhydrase [2],caspase[3] and cyclooxygenase-2 (PTGS2) are of other applications [4].Some examples of therapeutically important sulfonamides are sildenafil, amprenavir, celebrex and darunavir. To date, significant efforts have been allocated for the synthesis of sulfonamides in which all of them use from reactive amines in which lack from the requirement of additional protection/deprotectionsteps.Herein, we wish to disclose a general and novel strategy for the sulfonamidation of un-reactive amines.