چكيده فارسي :
Using the non-toxic and environmentally friendly reagents is one of the goals of green
chemistry. One of the main components of mostorganic reactions is catalyst. The use of green
and non-toxic catalyst is an important issue in a chemical reaction and of particular interested
to researchers.Employment of heterogeneous or heterogenized homogeneous catalytic
systems, utilization of organic compounds, organocatalysts, and designing the catalytic
systems based on environmentally friendly compounds such as ionic liquids are among the
attempts that have beenmade in recent years to bring the catalysts closer to the aims of green
chemistry. Recently, deep eutectic solvents (DESs) have emerged.
DESs are peers of the conventional ionic liquids (ILs)and as they have low vapor pressure
and low flammability [1]. Themain difference between these two families of compounds is
that ILsare neither biodegradable nor cost-effective but DESs are biodegradable,non-toxic,
inexpensive, and easily prepared.
Due to their presence in natural products, pharmaceutical, and many biologically active
molecules, as well as their role as intermediates in the synthesis of fine chemicals and dyes,
amine structure has become an important component in chemistry[2] Despite the development
of several synthetic methods for the preparing of these compounds in recent years[3] the
direct reductive amination of carbonyl compounds is still the powerful tool for this purpose.
In this study, we are going to report the synthesis of secondary amines by reductive amination
of aldehydes/ketones in the presence of DES (ChCl/Urea) as catalyst and NaBH4 as a
reducing agent in MeOH (Figure 1).
