Design, synthesis and catalytic application of a new ionic liquid functionalized silica coated magnetic nanoparticles as a reusable heterogeneous promoter for the synthesis of polyhydroquinolines

In recent times, development and expanding of the magnetic nano particles as versatile supports be revealed as an influential branch in the field of green chemistry due to the environmentally benign nature of these compounds. For the reason of easy separation of the magnetically based materials from the reaction system, manyattempts were focusedfor the surface modification of them in order to constructvaried heterogeneous magnetically recoverable promoters for the organic functional transformation [1]. Due to the varied pharmaceutical and biological applications connected to the polyhydroquinolines structural motif, huge attention have been paid for the production of these versatile organic compounds. Substituted 1,4-dihydropyridines are renowned as calcium channel modulators and they can be applied as a treatment for the therapy of the cardiovascular diseases [2]. Herein, we wish to introduce{Fe3O4@SiO2@(CH2)3Im}C(NO2)3 as a novel, green and heterogeneous reusable catalyst for the four component preparation of the polyhydroquinoline derivatives under mild and eco-friendly reaction conditions (Figure 1).