چكيده فارسي :
Imidazole derivatives including 4,5-dicyanoimidazoles exhibit a wide range of
pharmacological activities and have broad applications in medicinal [1]. The spectral and
photophysical characteristics this compounds attracted high interest for the synthesis as new
promising acceptor moiety [2].
According to importance of this compounds, up to now, four methods have reported for the
synthesis of these compounds, all of which are pathway for their synthesis of Schiff-base.
However, the most of these methods have some limitations such as refluxing for 4 days, use
of expensive and toxic catalysts or reagents, low yields, long reaction times and tedious
workup procedure [3].
In view of these points and as a part of our interest researches on the development of new
methods for the facile synthesis of 4,5-dicyanoimidazoles, we reported the condensation
reaction of 2,3-diaminomaleonitrileand aromatic aldehydes and following thatoxidative
cyclization reaction in the presence of catalytic amount of Cerium(IV) Ammonium nitrate
(CAN) and HNO3 in acetonitrile (Scheme 1). Some of the major advantages of this practical
procedure are use of available catalyst, high yields, short reaction timescompared with
previous reports, and simplicity of the reaction and workup.
