Efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones using (Fe3O4@SiO2-NH-) a reusable catalyst

(Fe3O4@SiO2-NH-) was found to nanocatalyst efficiently a One-Pot three-component cyclocondensation of isatoic anhydride and primary amines or ethylene amine with aromatic aldehydes under solvent free conditions to afford the corresponding mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones in good yields. The adventure of these catalytic condensation reactions represent green chemical processes, high yields, short reaction time and eco-friendly catalyst. One of the most important organic compounds are quinazolinones. Quinazoline and their derivatives have been reported to possess varied pharmacological properties including antitumor, anti-cancer, diuretic activities, anticonvulsant, anti-inflammatory, antimalarial and antihypertensive [1].For these reasons, much attention has been paid to the synthesis and biological evaluation of quinazoline derivatives. Several methods have been reported for the synthesis of 2,3-dihydroquinazolinone derivatives through One-Pot condensation of isatoic anhydride and amines with aldehydes [2-4] Nanocatalysis is recently developing field and is most important component of ―sustainable technology and organic transformations‖ applicable to almost all types‘ catalytic organic transformations. Among nanocatalysts, several forms such as magnetic nanocatalysts, nano mixed metal oxides, core-shell nanocatalysts, nano-supported catalysts, graphene-based nanocatalysts have been employed in catalytic applications [5]..