چكيده فارسي :
As we know, over the past decade, the environmental protection and waste prevention
have been an increasing emphasis among researchers from both academia and industryfor
elimination or reduce of volatile solvents in organic synthesis is a most important goal in
Green chemistry [1]. Acyl hydrazides are suitable molecules in the synthesis of some
imoportant products with pharmacologic activity such as β-Glucuronidase inhibitors [2],
Indoles [3]. In this project, we report an eco-friendly method for the synthesis of new acyl
hydrazide derivativesby direct alkylation of acyl hydrazides1 with dihaloalkanes 2 in the
presence of base 1,4-diazabiscyclo[2,2,2]octane and organic salt tetrabutylammoniumbromide
under solvent-free conditions (Figure 1)
The products were obtained in good to high yields within 18 h. TBAB was recovered and
reused for three times without notable reduction in its catalyst properties. We used the 1H
NMR (400 MHz) and 13C NMR (100 MHz), and IR technique to characterization of all
products structure. In summary, we have described an efficient method for the synthesis new
compounds that these potentially valuable products would make method practical and useful
to synthetic chemists..
