FeCl3-catalized formation of indolizine derivatives via 1,3-dipolar cycloaddition between azomethine ylide (1,3-dipole) and chalcone (electron-poor dienophile)

The C-H bond activation by using iodine mediated sp3 C-H functionalization for the synthesis of alkyl azaarenepyridinium zwitterions showed.[1,2]FeCl3-catalized 1,3-dipolar cycloaddition reaction of pyridinium-1-yl(quinolin-2-yl)methanides (prepared in situ from iodine catalyzed reaction of 2-methylquinoline and pyridine in the presence of base) with chalcones leading to a facile, One-Pot synthesis of aryl(2-aryl-3-(quinolin-2-yl)indolizin-1- yl)methanones in moderate to good yields.Various aspects of these transformations will be presented and discussed.