Homopiperazine sulfamic acid functionalized mesoporous silica nanoparticles (MSNs-HPZ-SO3H) as an efficient catalyst for one-pot synthesis of 1-amidoalkyl-2-naphthols

Multicomponent reactions (MCRs) are very elegant and efficient methods for accessing complex structures in a single synthetic operation from the corresponding building blocks. The MCRs are often carried out in One-Pot and designed to go through easy procedures with high atom-economy and great selectivity. This is mostly due to the generation of carbon– carbon and carbon heteroatom bonds.1One of these MCRs is the preparation of 1-amidoalkyl- 2-naphthols.These compounds and their derivatives which bear 1, 3-amino oxygenated functional groups have attracted intense attention.Therefore, it is still desirable to seek novel catalysts that are recyclable and capable of performing the reaction under mild conditions. On the other hand, recently mesoporous materials have received much attention,particularly those that are designed based on functionalized mesoporous silicas because of their high surface area, tunable nanoscale pores, ease of the grafting of organic scaffolds to balance between the hydrophilic and hydrophobic character of the porous architecture, exciting host−guest chemistry, and supramolecular interaction to different extents with the reactant molecules. 2,3Here in, we have developed a synthetic strategy for the design of a Homopiperazinesulfamic acid functionalized mesoporous silica ( MSNs-HPZ-SO3H) and its use as an efficient nanocatalyst for the One-Pot synthesis of 1-amidoalkyl-2-naphthols via three-component reaction of β-naphthol, aldehydes, and amides/urea, under solvent-free conditions.