چكيده فارسي :
Room temperature Ionic liquids represent a class of alternative green solvents receiving currently serious consideration is not only important on the laboratory scale but also for industrial applications with the promise of benefits both environmental and technological. By virtue of their nonflammable, chemical and thermal stability, and outstanding solvation ability and negligible vapour pressure ionic liquids have been proposed as new solvents [1]. Unfortunately, cost, toxicity for some aquatic species and high purity are the main disadvantage of these green solvents that limited for chemist and industry. On the other hands, deep eutectic solvent (DES) consisting of an ammonium salt and hydrogen-bond donor compounds such as urea, acid, amine, and carbohydrates are alternatives to ionic liquids for organic transformations [2]. These green and stable eutectic based solvents are cheaper, easier to make; it is necessary to take the two or three solids, mix them together and heat until melt. Furthermore, choline chloride ChCl and urea is both the naturally occurring biocompatible compound as they are easily biodegradable and are not hazardous if they are released back into nature, so processes that use this deep eutectic solvent is economically green [3].
As a part of our research aimed at developing green chemistry by using water and deep eutectic solvent such as urea-choline chloride as a reaction medium. Herein, we describe a simple, highly efficient One-Pot multicomponent reaction (Ugi, Passerini and other important MCR) in deep eutectic solvent under mild reaction condition and excellent yields.
