Noncovalent functionalization of graphene oxide with Schiff bases compounds as antibacterial materials

Graphene is a singleatomthick two-dimensional graphiticcarbon material. In the field of biomedicine,functionalized graphenes have been used for drug delivery, gene transfection,biosensing, as well as tumorimaging and photothermal therapy [1].Recently,research attention has been drawn towards the antibacterialactivity of graphene and graphenebasedNanocomposites [2]. Although whether and how graphene oxide(GO) presents antibacterial activity are still under debatebut suggested that the GO antimicrobial action contributes to both membrane disruption and oxidative stress [3]. Graphene oxide is produced by Hummer method. The Schiff base compounds were placed on the graphene oxide surface by non-covalent approach. It seems that π-π stacking interactions between the rings of chromene and graphene, is the most important factor for staying compounds on the surface of graphene oxide. The structure of the synthesized compounds was confirmed by FT-IR, UV-VIS, EDX and FE-SEM analysis. The purpose of synthesis these hybrid nanomaterials, is evaluation of their antimicrobial activity on the Escherichia coliand Staphylococcus aureus microorganisms.