SALTING-OUT EFFECT IN POLYPROPYLENE GLYCOL-AMINO ACID AQUEOUS SOLUTIONS REVEALED BY VAPOR PRESSURE OSMOMETRY

Precise vapor pressure osmometry measurements at T = 303.15, 308.15 and 313.15 K have been performed for low concentrations of different binary and ternary aqueous solutions including: amino acids (glycine, alanine, serine and proline) in pure water, PPG725 in pure water and amino acids in aqueous solutions of 0.01 w/w PPG725. In order to study the salting effects occurring in polymer-amino acid aqueous systems, deviations from the semi-ideal behavior have been evaluated. The results indicate that because of unfavorable interactions between PPG and amino acids, they are preferentially hydrated in aqueous media. Therefore, the amount of free water molecules in the PPG + amino acid + water solutions is less than that expected based on the semi-ideal behavior.