RESEARCH COMMUNICATION BINDING OF SERTRALINE TO HUMAN SERUM ALBUMIN

Human serum albumin is the version of serum albumin found in human blood. It is the most abundant protein in human blood plasma; it constitutes about half of serum protein and transport proteins for a variety of endogenous and exogenous substances such as fatty acids, hormones and drugs. Docking simulations using multiple template structures of human serum albumin from three crystal structures of complexes between drug and human serum albumin have demonstrated Sertraline drug bind with site II of Human serum albumin. More investigation also revealed that these Sertraline drug bind to the amino acids on the hydrophobic pocket of human serum albumin and not change to the secondary structure of the human serum albumin with free binding energy of -7.48 kcal mol-1.