PREPARATION OF MODIFIED NANOCOMPOSITES AS A NONOSORBENT FOR PRECONCENTRATION AND DETERMINATION OF RUTOSIDE IN BLOOD PLASMA AND URINE

The first study on the high efficiency of nanoparticles (SBA-15) coated graphene oxide as a new sorbent solid phase extraction has been reported. Modified nanicomposites was used to preconcentrate and determination rutoside drug in blood plasma and urine samples. These nanocomposites were characterized by thermo gravimetric analysis (TGA). The extraction conditions were optimized by selecting the appropriate extraction parameters including the amount of nanosorbent, pH value, type of eluting solution. The detection limit of this method for rutoside was 7.58 ng ml-1 and the R.S.D. was 1.6% (n=6). The advantages of this new method include rapidity, easy preparation of nanosorbents and a high preconcentration factor. The proposed method has been applied to the determination of rutoside drug at trace levels in real samples such as, blood plasma and urine with satisfactory results.