Molecular study of programmed cell death pathways in cancer

Programmed cell death (PCD), referring to apoptosis, autophagy, and necrosis programmed, represents a pathological cell death in a format that is mediated by an intracellular program takes place. Apoptosis is a morphological pattern of cell death during embryogenies and development of hormone-dependent tissues in the cytotoxicity of T cells and occurs in some pathologic conditions. Apoptosis including DNA rapid damage probably through the activation of endogenous endonucleases and premature chromatin condensation and fragmentation, followed by cell lysis. Apoptosis has two external paths or death receptor-induced apoptosis and internal path or mitochondrial apoptosis pathway. Necrosis collection of morphological changes that occur following the death of cells in living tissue or organ. Two processes led to fundamental changes in the morphological necrosis are 1) the changing nature of proteins 2) Remove organelles and cytosol enzyme. Caspases are a family of cysteine proteases that play a central role in the initiation phase apoptosis executive. Following activation, these enzymes act on specific substrates and biochemical and morphological changes of the apoptotic cell may be created. Including cell shrinkage, chromatin condensation, DNA fragmentation, and so on. So caspase activity evaluation as a biochemical marker apoptosis. While autophagy can be both pro-survival and pro-death. In this study, we brief the contents of apoptosis, autophagy, and necrosis programmed pathways in cancer to consider.