Computational Simulation of Neuronal Cell Response under Blast Loading With Considering Negative Pressure Phase in the Blast Load

Traumatic brain injury states to brain damage causing from sudden trauma. This is very important to understand the mechanism and effects of such damages to the brain toward the treatment for injuries. Change in membrane permeability and membrane disruption might be the earliest cell response to a blast load. A computational framework for considering the response of neuronal cell was presented. The negative pressure phase was also considered in blast load. Finite elements method with fluid-structure interactions were used in the simulation. Cell constituents were assumed to follow viscohyperelastic mechanical behavior. The Hugoniot/Mie-Gruneisen equation of state was used for propagation of shock waves in the water. The results showed that the peak overpressure and duration of the positive phase of blast loads play an important role in cell response. Finally, the results could be effective in the potential treatments after traumatic brain injury and also diagnosis of brain damages.