Study of the electrochemical behavior of Piroxicam on carbon ceramic modified electrodes with prussian blue complex by sol-gel technique

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class used to relieve the symptoms of painful, inflammatory conditions like arthritis [1]. a novel chemically modified electrode containing Prussian blue complex was achieved on the surface of glass carbon electrode by sol-gel technique [2-4]. The electrochemical behavior of modified electrode was characterized by cyclic voltammetry in detail. The film electrode obtained was very stable and exhibited electrocatalytic response for oxidation of piroxicam. Results showed at bare GC electrode, a small oxidation peak current was observed at about 0.6V and a well-formed sharp catalytic oxidation peak at about 0.54V was observed at Prussian blue complexe modified electrode. The electrocatalytic efficiency of the modified electrode towards piroxicam oxidation depends on solution pH, and optimum pH value for oxidation of piroxicam is 7.0. The detection limit of 0.1 μg ml−1 was obtained for piroxicam determination .The transfer coefficient (α) for electrocatalytic oxidation of piroxicam and the diffusion coefficient of this substance under the experimental conditions were also investigated.