Spectroscopic studies on charge-transfer complexes of Lidocaine drug with some electron acceptors

Recently many studies have been widely reported about the rapid interactions between different kinds of drugs and related compounds as donors with several types of δ and π-electron acceptors. Various spectroscopic techniques were used to characterize different types of complexes[1]. The formation of CT-complex were studied using UV-Vis and FT-IR spectroscopic techniques. Accordingly photometric titration measurements the formation of CT-complexes solution shows that in three system the molar ratio of the donor to the acceptor is 1:1 and accordingly complexes with this mode [(LIDH)(HCA)], [(LID)(DDQ)] and[(LID-I+)I-] were formulated. one of the the proposed mechanism are shown at the bottom[2]. The formation constant (KCT) and molar absorption coefficient (εCT) by using Benesi-Hildebrand equation and other thermodynamic parameters of formation CT-complexes such as standard free energy (∆G0), charge transfer energy (ECT) and ionization potential (IP) calculated and discussed.