A sensitive electrochemical sensor for pyridoxine based on layered double hydroxide/magnetic nanoparticles hybrid modified glassy carbon electrode

In recent years, development of electrochemical sensors based on nano–structured materials has attracted special attention of electrochemists due to their unique properties. Nanometerials can act as conduction centers facilitating the transfer of electrons and provide great catalytic surface areas [1]. Layered double hydroxides (LDHs) as class of the promising nanomaterials have been applied for this purpose. LDHs are attractive materials as electrode surface modifications owing to their many advantages such as large surface area, ease of preparation, low cost, tunable composition and electrocatalysis properties. Most recently, hybrid LDH materials have been developed, which have potential applications as electrode materials [2]. The performance of LDHs as electrode material can be improved by the incorporation of magnetic nanoparticles (MNPs) into LDHs.In this work, an electrochemical sensor for pyridoxine based on LDH/MNPs hybrid was presented. The as-synthesized nano-structured materials were characterized by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis, X-ray diffraction (XRD) and Fourier transform IR (FT–IR). The LDH/MNPs modified glassy carbon electrode exhibited good electrocatalytic activity toward the oxidation of pyridoxine due to the outstanding synergistic effect of LDH and MNPs. The electrochemical behavior of pyridoxine on the LDH/MNPs/GCE was investigated in detail. Under optimal experimental conditions, the current response of the fabricated sensor obtained via differential pulse voltammetry was increased linearly with pyridoxine concentrations in the wide range from 6.0×10–7 to 4.0×10–4 mol L–1, with a detection limit of 3.4 ×10–7 mol L–1 (S/N = 3). The proposed sensor was applied to determination of pyridoxine in pharmaceutical formulation. The fabricated sensor has remarkable characteristics such as high sensitivity, good repeatability, appreciable stability and low cost.