Synthesis of (3-p-tolyl-isoxazol-5-yl)methyl pantanoate

Isoxazole derivatives have been used a key intermediates in synthesize and have been investigated intensively for the last several years because of biological activities [1]. In spite of this wide spectrum of properties, the number of isoxazole tri-substituted isoxazole different functional groups, useful as scaffolds in the synthesis of many differently tri-substituted isoxazole, is scare [2]. This research work describes the synthesis of new compound of isoxazole family. In this work, some new compounds of isoxazole family were synthesized and characterized. First, 4-methylbenzaldehyde (1) was transformed to 4-methylbenzaldoxim (2) by using NH2OH in pyridine. The in situ generated nitriloxide from reaction between (2) and NaOCl, was reacted with propargylalcohol to product (3-p-Tolyl-isoxazol-5-yl)-methanol in a cycloaddition procedure. Then, the esterification was occurred with pentatonic acid and produced (3-p-tolyl-isoxazol-5-yl)methyl pantanoate 4 as a new compound. The structures of obtained products are certified by 1H and 13C NMR spectra.