Evaluation of the protective effect of the ginger and thyme extract on hemorrhagic necrotic enteritis with antibiotic therapy in dog animal model

Objectives: Increased resistance to antibiotics caused routine infection become fatal cases;and can cause influence and application failurein many modern treatments. Effectiveness of some plants with antibacterial properties as well as combining herbs with antibiotics are known to improve intestinal diseases, since ginger and thyme have antibacterial properties.Materials Methods: In this studyprotective effect of these two plants with antibiotic therapy were evaluated for treatment of hemorrhagic enteritis caused by bacteria such as E. coli, clostridium, campylobacter and salmonella. In an experiment with 50 dogs, 54 percent were with E. coli, 32 percent with salmonella, 30 percent campylobacter and 12 percent were with clostridium that meanwhile E. coli introduced as the main cause of hemorrhagic enteritis with the most prevalence. Treatment includes ginger and thyme extract and 3 types of antibiotics, including gentamicin, ceftriaxone and cefixime.Results Conclusion:Results showed that these two extracts showed no significant effect on bacterial growthsolely; while combination of ginger, thyme and gentamicin have a significant effect on sensitivity in E. coli, and also combination of these two extracts had more productivity effect; and associated with ceftriaxone and cefixime showed significant effects on E. coli and salmonella growth, while failed to affect on campylobacter.