پديدآورندگان :
Ali Shahrukh Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan , Ovais Omer Muhammad ovomer@gmail.com Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan , Ashraf Muhammad Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan , Bukhsh Allah Institute of Pharmaceutical Sciences,University of Veterinary and Animal Sciences, Lahore, 54000, Punjab, Pakistan , Chaudhry Mueen Ahmad Faculty of Pharmacy, The University of Lahore, Lahore,54000, Punjab, Pakistan , Qureshi Hassan Mahmood Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, 54000, Punjab, Pakistan
كليدواژه :
Equisetum debile , Antihistaminic , Anticholinergic , Bronchospasm , Spasmolytic , Antiasthmatic.
چكيده فارسي :
This project was designed to evaluate antihistaminic and anticholinergic activities of ethanolic and aqueous extracts of Equisetum debile. To evaluate antihistaminic and anticholinergic activities, E debile ethanolic(Ed.Eth) and E.debileaqueous (Ed.Aq) extracts were studied on isolated guinea pig ileum, rabbit jejunum and trachea mounted in tissue organ bath filled with physiological solution, aerated with carbogen and maintained at 370C. Tissue responses were measured by using isotonic and isometric transducers, connected with Power Lab Data Acquisition System. Ed.Eth and Ed.Aq showed a dose dependent (0.1-0.3 mg/ml) rightward shift in histamine concentration response curves and a more suppressant effect was observed in the case of Ed.Eth. Similarly, when tested on carbachol(1µM) induced pre contracted isolated jejunum and tracheal preparations, each tissue was completely relaxed at same dose of Ed.Aq and Ed.Eth with dose dependent significant (p 0.01) mannerbut Ed.Eth showed significance at more no of dose compare to Ed.Aq. These data strongly suggest the presence of antihistaminic and anticholinergic properties in ethanolic and aqueous extracts of E.debileplant, which can be useful in the management of airways and gastrointestinal disorders.
