Effect of Zinc nanoparticles on Arsenic-induced hepatotoxicity in rats

Objectives: The aim of the present study was to assess the effect of zinc nanoparticles on arsenic-induced hepatotoxicity in rats. Materials Methods: Four groups of rats were used as group1: control; group2: sodium arsenite; group3: zinc nanoparticles; group4: sodium arsenite + zinc nanopraticles. Drugs were intrapritoneally administrated for 10 days. The serum of rats was collected and analyzed biochemically. Liver tissue was routinely processed for histopathological examination. The results showed that ALT, AST and ALK was significantly decreased by zinc nanopraticles. Histopathological changes such as cell swelling, cloudy swelling, pyknosis, nuclear dust were observed.Results: These results indicated that zinc nanopraticles has protective effect on arsenic-induced hepatotoxicity probably by antioxidant action