Female mice Folliculogenesis influenced by Achillea millefolium L.

Objectives: Achillea millefolium or yarrow is a native plant in Europe and Iran. Yarrow has been used as a medicine historically, mainly because of its astringent effects. It is reported to be associated with the treatment of several uses of plants for medical purpose has become very common. Achillea millefolium L, Yarrow, is being used in traditional and modern medicine due to various chemical compounds. Considering the importance of birth control, finding a drug with fewer side effects inhibiting folliculogenesis seems to be necessary. The aim of the present study was to investigate the effect of ethanol extract of Achillea millefolium L. on folliculogenesis of female surri mice.Materials methods: In this study, 30 adult female surri mice were used. The animals were divided to three groups of ten mice. The first group, received 400 mg/kg Achillea millefolium L interaperitoneally, the second groups received 800 mg/kg Achillea millefolium L. interaperitoneally, respectively. In the third group (control) distilled water was administered. After 20 days, the mice were sacrificed and o tissues were histologically evaluated. Results: Comparing to control group, in the experimental groups received the high doses of the extract, loss of germinal epithelium and follicular growth were demonstrated (P 0.001). Based on the results, high concentrations of Achillea millefolium L. leaded to structural and folliculogenesis changes in ovary tissue