پديدآورندگان :
Askari H Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran , Seifi B b-seifi@tums.ac.ir Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran , Kadkhodaee M Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran , Elshiekh M Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran , Ranjbaran M Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
كليدواژه :
Chronic kidney disease , Proteinuria , Blood pressure , Oxidative status , 5 , 6 nephrectomy.
چكيده فارسي :
Objectives: Five-sixth nephrectomyis used as a model for induction of chronic kidney disease (CKD) in rats. To understand the pathophysiology of CKD, the present study was designed to assess the effects of 5/6 nephrectomy on proteinuria, blood pressure and renal oxidative status in rats.Materials Methods: CKD was induced in rats via 5/6 nephrectomy. Rats were divided into two groups, the sham group and the CKD group. Renal failure was followed at 12 weeks after the surgery by measuring systolic blood pressure and proteinuria. To evaluate the changes of the oxidative stress parameters, the levels of malondialdehyde (MDA) and superoxide dismutase (SOD) activities were measured in the kidneys.Results Conclusion: Compared with sham group, blood pressure increased in CKD group (Systolic blood pressure 150 mmHg). There was a significant increase in MDA level and urine protein among CKD rats. The data showed that activity of SOD decreased in 5/6 nephrectomized rats. In summary, 5/6 nephrectomy-induced kidney damage consistently give rise to renal dysfunction and oxidative status imbalance. Subtotal nephrectomy in the rat leads to a model of CKD that resembles human CKD and allows study of causal mechanisms and advantage of therapeutic interventions in CKD
