پديدآورندگان :
Kaboutari Katadj Jahangir Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran , Arab Hosseinali Department of Physiology, Pharmacology Toxicology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran , Habibian Dehkordi Saied Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran , Rafiean Mahmood Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
كليدواژه :
Artemisinin , single dose , serum level , chickens , HPLC
چكيده فارسي :
Objectives: Despite that preliminary studies have shown suitable anticoccidial effects of Artemisinin in broiler chickens but there were no studies about its pharmacokinetics, so this study was conducted to determine serum level of artemisinin in broiler chickens following single oral administration.Material Methods: 240-one day Ross chickens were divided randomly into two 8 groups each with three replicates (n=10). After dissolution in ethanol and dilution 0, 1, 5, 25, 125, 250, 500 1000 mg/kg artemisinin on day 44 was administered via gavage method and after 1hour blood sampling and then after serum separation were done. HPLC system with Uv detector was used to determine serum level of artemisinin. Data were presented as Mean±SE analyzed using Linear mixed model (P 0.05).Results and Conclusion: The levels of artemisinin in the chickens received single doses were in the range of 25.3804 ± 0.1533 to 42.2793 ± 12.0474 ng/ml, and there were no significant differences between different doses (p 0.05). Serum level of artemisinin administered orally to the chickens as single doses was very low which seems to be due to low oral absorption and metabolism induction and can be a key role for its high therapeutic index and good anticoccidial properties.
