Use of Nano-Clays as a topical hemostatic agent in animal model

Severe blood loss due to trauma is life threatening for the wounded in battle fields, civilian victims of vehicle accidents, street violence, wilderness accidents and construction incidents. Rapid hemostasis is crucial not only for decreasing mortality in these conditions, but also for optimal recovery. In this study, combination of different Nano-clays (NCs) is used as a topical hemostatic agent in a lethal rabbit model of complex groin injury. The mortality in the NSc group (25.0%) is significantly less than that in the control group (56. %). When NCs comes into contact with blood, it rapidly adsorbs water from the blood and holds the water molecules in the pores by hydrogen bonds. Additionally, the negative charge surface provides key surface chemistry, rapidly activating the coagulation process and promoted local hemostasis.