شماره ركورد كنفرانس :
4046
عنوان مقاله :
Molecular Docking Study of the Interactions between Nalidixic acid with Human Serum Albumin
عنوان به زبان ديگر :
Molecular Docking Study of the Interactions between Nalidixic acid with Human Serum Albumin
پديدآورندگان :
Nabipour Hafezeh ha.nabipour@gmail.com Biomaterials Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj, Iran. , Taherkhani Saeid ha.nabipour@gmail.com Islamic Azad University , Pakzad, Yousef ha.nabipour@gmail.com 1Biomaterials Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj, Iran.;
كليدواژه :
Molecular Docking , Interaction , Nalidixic acid , HAS
عنوان كنفرانس :
چهارمين كنفرانس بين المللي نوآوري هاي اخير در شيمي و مهندسي شيمي
چكيده فارسي :
Human serum albumin (HSA) is one of the main endogenous carriers for biodistribution of molecules by blood plasma. Inhabitation constants and thermodynamic parameters (ΔH and ΔG) for the interaction of HSA with nalidixic acid were studied by molecular docking. The hydrogen-bond forces were found to stabilize the nalidixic acid–HSA complex. Furthermore, the molecular modeling was employed for characterization of drug binding sites and interaction of nalidixic acid with amino acid residues. Results confirmed the presence of this drug in 1 site of HSA and indicated that the driving force between NA and HSA was mainly typical hydrophilic interaction.
