Electrochemical determination of doxorubicin in pharmaceutical samples using nanostructure sensor

Cancer is a serious disease and an important cause of mortality in humans from many years ago. Many attempts have been made to treat cancer by scientist. Application of anticancer drugs in chemotherapy is the main way for treatment of cancer. Doxorubicin can be interferes with the growth and spread of cancer cells and helps to treatment of cancer and especially breast cancer. The electrochemical oxidation of oxorubicin was investigated at a ZnO nanoparticle/1-butyl-3-methylimidazolium tetrafluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE). Doxorubicin could exhibit a good quasi-reversible signal with high sensitivity at a surface of ZnO-NPs/BMTFB/CPE compare to unmodified electrode. The ZnO-NPs was biosynthesized by celery extract and used for modification of carbon paste electrode. In addition, the ZnO-NPs/BMTFB/CPE exhibits two separated oxidation signals for simultaneous analysis of doxorubicin and dasatinib with ΔE~ 300 mV. Finally, the ZnO-NPs/BMTFB/CPE showed good ability for analysis of doxorubicin and dasatinib in injection and serum samples.