ZIF-8-based microextraction method for determination of fluoxetine in water samples

Sample extraction is a major step in environmental analyses due both to the high complexity of matrices and to the low concentration of the target analytes [1]. Sample extraction is usually expensive, laborious, timeconsuming and requires a high amount of organic solvents [2]. Actually, there is a lack of miniaturized methodologies for sample extraction and chiral analyses. Here, we developed a ZIF-8-based thin film microextraction (TFME) to extract the pharmaceuticals fluoxetine as model of basic chiral compounds, from wastewater samples [3]. Compounds were then analysed by enantioselective high-performance liquid chromatography. We monitored the influence of sample pH, extracting and dispersive solvent and respective volumes, salt addition and extracting time. The proposed method gives a very rapid, simple, sensitive and low–cost procedure for the determination of fluoxetine.