Aplplication of Molecular Imprinted Polymers In The Fabrication of Biosensor And Sensor Since 2015-2017

Molecularly Imprinted Polymers (MIPs) are artificial receptors that mimic natural recognition entities, with high selectivity for a given target analyte[1]. The QR imprinted poly(p-ABA) presented good recognition ability [2]. poly(o-phenylenediamine) film (PPD) was electropolymerized onto the carboxylic-group-functionalized SWCNHs (SWCNHs-COOH)-modified glassy carbon electrode to make electrochemical kanamycin MIP sensor. The resulting sensor has been successfully applied to analyze kanamycin with high sensitivity, selectivity, and recovery [3]. The developed electrochemical sensor exhibits an easy manufacture, a highly sensitive and selective sensing material [4]. Increasing interest has been given to microporous metal-organic frameworks (MMOF)as highly sensitive and selective platforms for the development of sensors [5]. Polydopamine (PDA) has been implemented as an excellent surface-adherent material for multifunctional coatings of membrane surfaces [6]. The synthetic sensor possesses advantages including simplicity, high specificity low cost of preparation, good chemical and mechanical properties, sensitive and label-free determination [7]. combining GO with MIP in the material design will result in higher affinity and exceptional sensitivity to a particulardetecting molecule due to its homogeneous distribution of recognition sites [8]. Boronic acid can combine with glucose or fructose in the imprinted polymer matrix according to covalently linkage, under the circumstances, it is a potential method to improve the selective detection of sugar [9]. The prepared GO-MIP based working electrode showed excellent catalytic activity against glucose [10]. In this paper polyvinyl acetate hasbeen chosen for its properties, such as water insolubility, low cost, simple usage and stability at room temperature [11]. Films of PPy and derivatives have good conductivity, selectivity, stability and efficient polymerization at neutral pH [12]. The MIP modified ISFET sensors also 13th Annual Electrochemistry Seminar of Iran Materials and Energy Research Center (MERC), 22- 23 Nov, 2017 81 exhibit excellent reproducibility, repeatability and stability, as well as high selectivity to urea [13]. Finally, in this article, we will try to show the hot articles of the MIP application in building the biosensor and sensor in the table. Table 1. Selected Examples of Functional Monomers Providing Defined Recognizing Sites in Imprinted Molecular Cavities Menomer Template Linear range LOD Refs Para amino benzoic acid quercetin 0.01 – 0.5 μM 5n M [2] o-phenylenediamine kanamycin 0.1 – 50 μM 0.1 μM [3] P-aminothiophenal tetracycline 22.4 nM – 224 f M 0.22 fM [4] P-aminothiophenal gemcitabine 318 fM – 38 nM 3 fM [5] amino thiophenol cholesterol 10-18 – 10-13 M 3.3 × 10-19 M [6] O - aminophenol cardiac troponin 0.05 – 5 nM 0.027 nM [7] methacrylic acid cholesterol 0.1 nM – 0.01 M 0.1 nM [8] 3-hydroxyphenylboronic acid-co-phenol glucose , fructose 0.75 – 18 mM 0.23 mM , 0.35 mM [9] methacrylic acid glucose 0.01 – 0.08 μM 0.1 nM [10] vinylacetate glucose 0.5 – 4.4 mM 53 μM [11] pyrrole cortisol 1 pM – 10 μM 1 PM L-1 [12] Methyl methacrylate urea 10-1 M – 10-4 M 10-4 M [13]