Amino Functionalize Zeolite: as an efficient catalyst in synthesis of 5-Substituted 1H-tetrazoles

The recoverability and reusability offered by heterogeneous systems, to give high yields in short times and sometimes without the need for organic material, lead to green chemistry. Zeolites are crystalline aluminosilicates whose internal voids are formed by cavities and channels of strictly regular dimensions and of different sizes and shapes. Also, design of the solventless systems as the relatively green source, has stirred up interest among organic chemists in recent years. We selected NaY zeolite for immobilization of sulfamic acid. In contrast, the presence of sodium ions in the crystalline matrix of Zeolite Y, gives NaY-NH2 a strong basic nature even without the grafted organic bases [1]. Tetrazoles with a 5-membered ring of four nitrogen and one carbon atoms are as important class of N-rich heterocycles. Due various applications this poly-aza-heterocyclic compounds have attracted significant attention such as in medicinal chemistry, and in material sciences [2]. A few of them derivatives exhibited biological potencies, such as antibacterial, antiinflammatory, antifungal, antiviral, antitubercolous, cyclo-oxygenase inhibitors, antinociceptive, hypoglycemic and anticancer activities [3] and this valiuable compounds have always been considered as important synthetic targets [4].