شماره ركورد كنفرانس :
4309
عنوان مقاله :
Hypericin induces apoptosis in MDA-MB231 cell line with no significant effect on normal cells
پديدآورندگان :
Abbasi Gamasaee Niusha Department of Molecular and Cellular Science, Faculty of Advanced Sciences Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran-Iran (IAUPS) , Shahriari Fatemeh Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. , Javidi Mohammad Amin maj136@gmail.com Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.Department of Molecular and Cellular Science, Faculty of Advanced Sciences Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran-Iran (IAUPS)و
تعداد صفحه :
1
كليدواژه :
Key words: Hypericin , Breast cancer , Triple negative , low , claudin
سال انتشار :
1395
عنوان كنفرانس :
سومين كنفرانس ملي علوم و تكنولوژي هاي نوين زيستي
زبان مدرك :
انگليسي
چكيده فارسي :
Breast cancer is the most common cancer among females worldwide. In recent molecular profiling of breast cancer which is based on hormone receptors and HER2 status along with proliferation markers, the Triple negative subtype poses the hardest one to treat and the one with the poorest prognosis. In this study we assessed the effect of Hepericin, a naturally occurring chromophore, on the MDA-MB-231 cell line. This cell line represents as a Triple negative/ low-claudin subtype. Hypericin is a fluorescent second metabolite with a broad pharmacological spectrum. Its selective accumulation in tumor microenvironment along with its potent photosensitizing feature made it a favorable candidate in anticancer photodynamic therapy (PDT) and photodynamic diagnosis (PDD) studies. Yet its own proapoptotic effects on cancerous cells has been less studied. In this study we investigated the different doses and exposure times of Hypericin on malignant and normal cells and studied its downstream apoptotic effects. Our results suggest that Hypericin can be a good candidate in the treatment of Triple negative breast cancer with the least side effects on normal tissues.
كشور :
ايران
لينک به اين مدرک :
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