weeks of aerobic exercise improve plasma levels of beta amyloid

Aging accompained by organ dysfunction, including central nervous system. Alzheimer s disease is the most common age-related disease and also is the most common neurodegenerative disease. The role of amyloid beta (Aβ) in Alzheimer widely documented. This study aimed to investigate the effect of 12 weeks aerobic exercise on plasma levels of Aβ42 and cognitive function in elderly females.30 elderly women living in nursing homes Bojnoord city aged between 60 and 70 years were randomly based on cognitive performance in the experimental group (n = 15) and control (n = 15) were placed. Aerobic exercise for 12 weeks, 3 days per week with 50-70% heart rate reserve was conducted. During the session, the first 30 minutes and with the passage of time and in the following sessions, the duration of training increased to 60 min. to evaluate the cognitive function, performance of short-term cognitive mental status examination (MMSE) was used. Plasma Aβ42 levels were measured using ELISA. Analyze data using dependent and independent t-test at a significance level of p 0/05 was performed. The results of the independent t test showed that Aβ42 levels in pre and post test in experimental and control groups there was no significant difrence (p 0/05). Comparison of the groups showed that 12 weeks of aerobic exercise has a significant impact on the level of Aβ42 plasma in elderly women (p=0/014) but the aerobic training didn t have any significant difference in the results of MMSE older women in pre and post test experimental group was observed (p=0/347). Chou et al (2010) demonstrated that 16 weeks of treadmill exercise in addition to taking alpha-lipoic acid reduced plasma levels of Aβ1-42 in 13 manths old with Alzheimer s of NSE / APPsw species results showed that exercise duration was effective in reducing Alzheimer s disease. in conclusion, the results sgowed that aerobic exercise have profitable effect on plasma levels of Aβ42 and cognitive function in elderly eomen and prpbably with increase exercise duration could have obviose effect on cognitive function.