Voltammetric determination of Doxorubicin using electrochemical sensor

Doxorubicin introduced as a useful anti-cancer drug for the treatment of breast cancer, lymphoma and bladder cancer in chemotherapy process[1]. Although doxorubicin showed a powerful ability in chemotherapy process, its high side effects, such as hair loss, nausea and immunosuppression are still a major challenge and the main problem; thus determines of its level in the human body is necessary for a chemotherapy process. In this study, we fabricated a highly sensitive electrochemical approach base on carbon paste electrode modified with 2D nitrogen doped reduced graphene nano-sheet and 1-methyl-3- octylimidazolium chloride for determination of doxorubicin. The NrG/MOICl/CPE as an anticancer sensor displayed detection limits of 3.1 nM and 0.27 μM for doxorubicin and topotecan, respectively. The NrG/MOICl/CPE was used for determination of doxorubicin in drug and urine samples.